Chemistry meets epigenetics: from chromatin tools to small molecules affecting the readout of our genomes.

by Fischle, Wolfgang, Schwarzer, Dirk
Year: 2018 ISSN: 1367-5931


The functional state of eukaryotic genomes is regulated by sequence-specific DNA binding factors and by the packaging state of DNA into chromatin. Dissection of the complex cross-talk of gene regulation and cellular inputs has been substantially aided by the development of chemical tools targeting the various factors and different components involved in these processes.